Twiga Study
HIV as a risk factor for geriatric syndromes, non-communicable diseases and mortality among adults aged 60 years and above in Kenya.
Duration
5 years
Population
≥60 years
Setting
Kenya
Prospective observational cohort study of adults aged 60 years and older over a 5-year follow-up period, comparing health outcomes, functional status, and quality of life based on HIV status. The study aims to understand the impact of HIV on the aging process in the Kenyan population through longitudinal tracking.
Primary Endpoint
Incidence of geriatric syndromes and non-communicable diseases
Adults aged 60 years and above living in Kenya, with and without HIV infection. Recruitment spans urban and rural healthcare facilities as well as community-based centers to ensure representative coverage across the Kenyan population.
Frailty
Physical weakness, slowness, and decreased activity levels in aging adults
Cognitive Decline
Memory impairment and changes in mental function over time
Falls & Mobility
Balance deterioration and increased risk of falls
Polypharmacy
Multiple concurrent medications and potential drug interactions
Cardiovascular disease (hypertension, heart disease)
Diabetes mellitus and metabolic disorders
Chronic kidney disease
Osteoporosis and bone disorders
Cancer screening and diagnosis
Mental health conditions (depression, anxiety)
Respiratory diseases
Liver disease and hepatitis co-infection